Imikhiqizo
Pyrimidine-2,4 (1h, 3h) -Dione; Case No.: 66-22-8
Amanyanjana: Uracil
Impahla yamakhemikhali yePyrimidine-2,4 (1h, 3H) -Dione
● Ukubukeka / umbala: i-powder emhlophe
● Ingcindezi ye-Vapor: 2.27e-08mmhg ngo-25 ° C
● Iphuzu elincibilikayo:> 300 ° C (lit.)
● Inkomba evulekayo: 1.501
● Iphuzu elibilayo: 440.5 ° C ku-760 mmhg
● I-PKA: 9.45 (ngo-25 ℃)
● Iphuzu le-Flash: 220.2OC
● Psa:65.72000
● Hlensity: 1.322 g / cm3
● logp: -0.93680
● Isitoreji Temp.:+15C ukuze + 30c
● I-Solubity.I-SOLUBITILINICE (Kancane), DMSO (kancane, ukufudumala, i-sonicated), i-methanol (kancane,
● Amanzi Solubilicility.:SOLUble emanzini ashisayo
● xLogp3: -1.1
● I-Hydrogen Bond Donor Count: 2
● Ukubalwa Kwama-Hydrogen Bond kwamukelwa: 2
● I-Rotatable Bond Count: 0
● Isisindo esiqondile: 112.027277375
● Isibalo se-atom esindayo: 8
● Ukuba yinkimbinkimbi: 161
Imininingwane Ephelile
● pictograph (s):
I-XI
● Amakhodi Ayingozi: XI
● Izitatimende zokuphepha: 22-24 / 25
-Sizayo
Amakilasi Amakhemikhali:Ama-Biological Agents -> Ama-Acid Acid and Derivatives
Ukumamatheka kwe-canonical:C1 = CNC (= o) nc1 = o
Imitholampilo yakamuva:Ukutadisha ka-0.1% uracil ukhilimu we-topical (UTC) wokuvimbela i-hand-foot syndrome
Izilingo zakamuva zemitholampilo ye-EU:I-Onderzoek de Farmacokinetiek van Uracil na Orale Toediening Bij Pati? Ntent Met Alepulaal Carcinoom.
Izilingo zakamuva zeNIPH Clinical: Isigaba II Isilingo samafutha e-Uracil sokuvimbela i-capecitabine eqediwe yesandla (HFS):.
Sebenzisa:Ngocwaningo lwe-biochemical, izidakamizwa synthesis; Ukusetshenziswa njenge-Intermediates yezemithi, futhi esetshenziswe kusisekelo se-organic synthesis nitrogenous kuma-rna nucleososides. antineoplastic ocwaningweni lwe-biochemical. U-Uracil (LamivuDedine EP ukungcola f) isisekelo se-nitrogenous ku-rna nucleososides.
Incazelo:I-Uracil isisekelo se-pyrimidine kanye nengxenye eyisisekelo ye-RNA lapho ibopha khona i-adenine ngezibopho ze-hydrogen. Iguqulwa ibe yi-uridine ye-nucleoside ngokungezwa kwe-ribose moosset, bese uye e-uridine ye-uridine ye-uridine ye-nucleotide ngokufakwa kweqembu le-phosphate.
Isingeniso Esinemininingwane
I-Uracil iyindawo ye-organic okungokomndeni we-pyrimidine derivatives. Kuyinto molecule ye-herocyclic aphungekile equkethe indandatho ye-pyrimidine enama-athomu amabili angu-nitrogen. I-Uracil inefomula yamakhemikhali c4h4N2O2 kanye nesisindo samangqamuzana esingu-112.09 g / mol.
I-Uracil ingelinye lama-nucleobase amane atholakala ezintweni zofuzo ze-RNA (Ribabacleic acid). Idlala indima ebalulekile ku-protein synthesis kanye ne-gene expression. Ku-RNA, ama-Uracil ngababili nge-adenine nge-hydrogen bonding, akha amabhondi amabili e-hydrogen, futhi lokhu kubhanqa kwalesi sisekelo kusiza ukufaka imininingwane yofuzo.
I-Uracil nayo ingatholakala kwamanye ama-molecule abalulekile endalo. Isibonelo, kuyingxenye ebalulekile ye-molecule ephethe amandla ebizwa nge-ATP (Adenosine Triphosphate). I-Uracil Derivatives, enjenge-5-Fluorouracil, isetshenziswe njengabaphathi bezimpikiswano ngenxa yekhono labo lokuphazamisa ukuphindaphinda kwe-DNA kanye nesigaba seseli.
Ngaphezu kokubaluleka kwayo kwemvelo, i-Uracil inezicelo ezahlukahlukene zamakhemikhali nezimboni. Isetshenziswa njengezinto zokuqala zokuhlanganiswa kwemithi yezemithi, ama-agrochemicals kanye nodayi. Ama-Uracil Derivatives nawo aqashwa ekukhiqizweni kwama-herbicides kanye nama-fungicides. Ngaphezu kwalokho, i-Uracil ingasetshenziswa njengophawu kumakhemikhali wokuhlaziya kanye nethuluzi lokucwaninga nge-molecular Biology.
I-Uracil iyi-crystalline emhlophe eqinile enyakazisa emanzini. Kuzinzile ngaphansi kwezimo ezijwayelekile kepha kungabhekana nokusabela kwamakhemikhali, njenge-oxidation kanye nokushintshana kokunye, ngaphansi kwemibandela ethile. I-Compound inephuzu lokuncibilika lika-335-338°C nephuzu elibilayo le-351-357°C.
Sekukonke, i-Uracil iyingxenye ebalulekile ezinqubweni zemvelo ze-RNA futhi inezicelo ezibalulekile kuzo zombili izimboni zebhayoloji kanye namakhemikhali.
Isicelo
I-Uracil inezicelo eziningi emikhakheni ehlukahlukene, kufaka phakathi:
Imboni Yezemithi:I-Uracil kanye nezinto zayo zokususelwa kwayo zisetshenziselwe ukuthuthukisa izidakamizwa ngezinhloso ezahlukahlukene. Isibonelo, ama-5-FluoRouracil asetshenziswa njenge-chemotherapy umuthi osetshenziswa ngayo ukwelapha izinhlobo ezithile zomdlavuza. Izidakamizwa ezi-antiviral ezisuselwa ku-Uracil ezisetshenziswayo, ezinjenge-Idochuridine ne-Trifluridine, zisetshenziselwa ukwelapha ukutheleleka nge-viral eye.
Ezolimo:I-Uracil Derivatives isetshenziswa ekukhiqizweni kwama-herbicides kanye nama-fungicides. Lezi zinhlanganisela zisiza ukulawula ukukhula kokhula futhi kuvikele izilimo ekuthelelekeni fungal.
I-Analytical Chemistry:I-Uracil ivame ukusetshenziswa njengophawu lwe-chromatographic noma indinganiso yangaphakathi ngezindlela zokuhlaziya zamakhemikhali. Ingasetshenziswa njengesethenjwa senkomba ukuthola isikhathi sokugcina nokuthola ezinye izinkwa zesampula.
Ucwaningo lwe-Molecular Biology:I-Uracil isetshenziswa kumasu ahlukahlukene we-molecular biologres, njenge-polymerase chain reaction (PCR), i-DNA ukulandelana, kanye ne-mutageneis eqondiswe esizeni. Isebenza njengethempulethi ye-DNA Synthesis noma njengengxenye yokwakha izinguquko ezithile ekulandeleni kwe-DNA.
Imboni yokudla:I-Uracil ngezikhathi ezithile isetshenziswa njenge-enhancer yokunambitheka embonini yokudla, ikakhulukazi ekukhiqizweni kokudla okusetshenzelwe kanye neziphuzo.
Izimonyo:Ama-Uracil Derivatives asetshenziswa emikhiqizweni yezimonyo zezakhiwo zawo ezinomswakama nezikhumba. Bangasiza ekuthuthukiseni i-hydration yesikhumba futhi bavikele ekuhlolweni kwezemvelo.
Ucwaningo Nentuthuko:I-Uracil nayo iqashwa ku-biochemical kanye nemithi yocwaningo njenge-realent noma i-Intermediate yokuhlanganisa ezinye izinhlanganisela ezinomsebenzi webhayoloji noma ukutadisha metabolism we-nucleic acid.
Ububanzi bezinhlelo zokusebenza ezibanzi ze-Uracil bukhombisa ukubaluleka kwayo emikhakheni efana nemithi, ezolimo, chemistry kanye ne-biotechnology. Abaphenyi bayaqhubeka nokuhlola izindlela ezintsha zokusebenzisa izakhiwo zayo ukuze baqhubeke nezindawo ezithuthukile kulezi zindawo.
