Imikhiqizo
N, n'-diisopropylcarbodiimiimiiimide; Case No.: 693-13-0-0
Amanyanjana: 1,3-diisopropylcalcarbodiimiimiimide
Impahla yamakhemikhali ye-n, n'-diisopropylcarbodiimiide
● Ukubukeka / Umbala: Ungenambala ophuzi ophuzi ophuzi
● Ingcindezi ye-Vapor: 34.9hpa ku-55.46 ℃
● Iphuzu elincibilikayo: 210-212 ° C (Dec)
● Inkomba eyethusayo: N20 / D 1.433 (lit.)
● Iphuzu elibilayo: 146.5 ° C ku-760 mmhg
● Iphuzu le-Flash: 33.9 ° C
● Psa:24.72000
● Hlensity: 0.83 g / cm3
● logp: 1.97710
● Isitoreji Temp.:2-8
● I-SENTITE.:moiture ebucayi
● I-Solubity.:SOLUble in Chloroform, Methylene Chloride, Acetonitrile, Dioxane
● xLogp3: 2.6
● I-Hydrogen Bond Donor Count: 0
● Ukubalwa Kwama-Hydrogen Bond kwamukelwa: 2
● I-rotatable Bond Count: 2
● Isisindo esiqondile: 126.115698455
● Isibalo se-athomu esindayo: 9
● Ukuba yinkimbinkimbi: 101
Imininingwane Ephelile
● pictograph (s): t +,
T,
E f
● Amakhodi Anobungozi: T +, T, F, XN
● Izitatimende: 10-26-36 / 37/38-41-42-37-37 / 38
● Izitatimende zokuphepha: 26-36 / 37/37-45-38-28A-16-22
-Sizayo
Amakilasi Amakhemikhali:Ama-Nitrogen Compounds -> Amanye amakhompiyutha we-nitrogen
Ukumamatheka kwe-canonical:Cc (c) n = c = nc (c) c
Izilingo zakamuva zemitholampilo ye-EU:Imiphumela yesikhathi eside ye-Aldara? I-5% ukhilimu futhi
Incazeloisopropylcarbodiimiide (DIC) iwuketshezi olucacile olungasatshalaliswa kalula ngevolumu. Ihlala kancane kancane ngomswakama ovela emoyeni, ngakho-ke ukugcinwa kwesikhathi eside ibhodlela kufanele lidonswe ngomoya owomile noma i-inert gas futhi livalwe ngokuqinile. Isetshenziswa kumakhemikhali we-peptide njenge-realegent ehlanganisiwe. Kunobuthi obunobuthi kakhulu futhi obangelwa yi-dermatitis yesisebenzi selebhu.
Sebenzisa:Lo mkhiqizo usetshenziswe ikakhulukazi ku-ampikacin, ama-dehydrants we-glutathione, kanye nase-synthesis we-anhydride anhydride, i-Aldehyde, iKetone, isocyanate; Lapho isetshenziswa njenge-ejenti evuthayo emzimbeni, iphendula nge-daicyclohexylurea ngokusabela kwesikhashana ngaphansi kokushisa okujwayelekile. Lo mkhiqizo ungasetshenziswa futhi ku-synthesis we-peptide ne-nucleic acid. Kulula ukusebenzisa lo mkhiqizo ukuze usabele nge-compact yamahhala ye-carpobox ne-amino-group ibe yi-peptide. Lo mkhiqizo usetshenziswa kabanzi kwezokwelapha, ezempilo, ukwakheka nemikhiqizo yemvelo, nakwamanye amasimu okwenziwa. N, n'-diisopropylcarbodiimiimiiimide isetshenziswa njenge-reagent kumakhemikhali we-organic zokwenziwa. Isebenza njengomphakathi wamakhemikhali futhi njenge-stabilizer ye-sarin (izikhali zamakhemikhali). Iphinde isetshenziswe ekuhlanganiseni kwe-peptide ne-nucleic acid. Ngaphezu kwalokho, isetshenziswa njenge-antineoooplastic futhi ibandakanyeka ekwelapheni i-melanoma ephathekayo kanye ne-sarcomas. Ngaphezu kwalokhu, isetshenziswa ekuhlolweni kwe-anhydride ye-acid, i-Aldehyde, iKetone ne-isocyanate.
Isingeniso Esinemininingwane
N, n'-diisopropylcarbodiimiide, okuvame ukufushaniswa njenge-dic, kuyindawo yamakhemikhali ngefomula ye-molecular c7h14N2. Kuwuketshezi olungenamibala oncibilikayo ezinhlamvwini ezijwayelekile ezifana nokuthambekela kanye notshwala. I-DIC isetshenziswa kabanzi njenge-organic syntherisis realent futhi idlala indima ebalulekile ekuphendukeni okuhlukahlukene kwamakhemikhali.
I-DIC isetshenziswa ngokuyinhloko njenge-ejenti ehlanganayo endaweni yokuhlanganiswa kwe-peptide, okuyinqubo yokujoyina ama-amino acid ndawonye ukwakha ama-peptides noma amaprotheni. Isebenza njenge-reagent evumelanayo, yenza lula ukuhlanganiswa kwama-amino acids ngokwenza kusebenze amaqembu e-carboxyl, ngokuvamile ngokwakheka komphakathi ongazinzile obizwa ngokuthi i-ester esebenzayo ebizwa ngokuthi i-ester esebenzayo ebizwa ngokuthi i-ester esebenzayo. Lo msakazi uphendula namaqembu e-Amino ngaphambi kokuhlelwa kabusha nokuqedwa ukukhiqiza isibopho se-peptide.
I-DIC nayo iqashwa kwezinye izindlela zokuphendula ngaphezu kokuhlobana kwamapeptide, njengokuchazwa, ukuphathwa, kanye nokuhlanganiswa kwe-urethethene. Isebenza njenge-ejenti yokuphelelwa ngamandla kulokhu kusabela, okwenza ukususwa kwama-molekyuli amanzi, ngaleyo ndlela kuqhubekele ekuphendukeni okufunayo phambili.
Ngenxa yokuvuselelwa kwayo nephunga elinamandla, i-dic kufanele iphathwe ngokuqapha. Ngokuvamile isetshenziswa kwi-hood ye-feme evuthayo enomoya omuhle kanye namagilavu avikelayo kufanele agqoke ukuvikela ukuxhumana kwesikhumba. Ngokwengeziwe, njenganoma yimaphi amakhemikhali, kubalulekile ukulandela izinqubo zokuphepha ezifanele futhi uthintane nephepha ledatha yokuphepha ngokwezinto ezibonakalayo (MSDS) ngemininingwane enemininingwane.
Ngamafuphi, n, n'iisopropylcarbodiimiide iyindlela eguquguqukayo esetshenziswa ekuhlanganiseni kwe-organic ngokusabela okuhlukahlukene, kufaka phakathi ukuhlanganiswa kwe-peptide, okuhlosiwe, nokuhlaziywa, kanye nokuhlanganiswa kwe-urethenane. Indima yayo njengo-Agelling Agent kanye ne-ejenti yokuphelelwa ngamandla kwenza kube yithuluzi elibalulekile emkhakheni wamakhemikhali we-organic.
Isicelo
N, n'-diisopropyclarbodiimiide (DIC) inezicelo ezimbalwa ezibalulekile ku-organic synthesis kanye nocwaningo lwezemithi. Nazi ezinye izinto ezisetshenziswayo ze-DIC:
Synthide synthesis:I-DIC isetshenziswa kakhulu njenge-ejenti ehlanganisiwe ekuhlanganiseni okuqinile kwesigaba se-peptide ukwakha ama-peptide bond phakathi kwama-amino acid. Isebenzisa amaqembu e-carboxyl avikelwe ama-amino acid, avumele ukuba aphendule namaqembu e-amino, okuholela ekwakhekeni kwamabhondi ama-peptide.
Ukuvuselelwa kwe-Admation kanye nokuvuselelwa kokuqonda:I-DIC iqashwa njenge-ejenti yokuphenya ngamanzi ukukhuthaza ukubuyiselwa kwama-carboxylic acid anezinwele noma ama-alcohols ekuvuseleleni okuhlangenwe nakho nokulandelana, ngokulandelana. Inika amandla ukwakheka kwezingadi nama-esters ngokususa amanzi kwinhlanganisela yokusabela.
Synane synthesis:I-DIC ingasetshenziswa njenge-ejenti yokuhlangana ngokuhlanganiswa kwezinhlanganisela ze-urethane. Inika amandla ukusabela phakathi kwama-isocyanates notshwala ukwakha ama-urethanes.
Ukusabela kokuhlanganiswa kwe-carbodiimide-medited:I-DIC ivame ukusetshenziswa njenge-realegent ehlanganisiwe ekuphendukeni okuhlukahlukene okuphathekayo, njengokuhlanganiswa kwezingalo, ama-peptides, nezinye izinhlanganisela ezisebenzayo ngokwezinto ezisebenzayo. Ikhuthaza ukuhlanganiswa kwama-carboxylic acid, ama-chloride e-acid, noma ama-acyl azides anezinwele, ama-hydroxylamine, namanye ama-nucleophiles.
Izinguquko ezi-oxidative:I-DIC ingasetshenziswa ekuphendukeni kwe-oxidative, njenge-cleavage ye-oxidative of Oxefins kanye ne-oxidation of sulfides kuma-sulfoxides noma ama-sulfone.
Kubalulekile ukuqaphela ukuthi i-dic iyi-air- kanye nomswakama-azwela, ngakho-ke kufanele iphathwe endaweni enomoya omuhle noma ngaphansi komoya we-inert. Ngaphezu kwalokho, izinyathelo zokuphepha, ezifana namagilavu kanye nama-goggles, kufanele kuthathwe lapho usebenza nge-dic ngenxa yemvelo yayo eyingozi.
