Isithombe Esifakiwe se-N-Methyl-2-pyrrolidone

I-N-Methyl-2-pyrrolidone

Incazelo emfushane:

Igama Lomkhiqizo:I-N-Methyl-2-pyrrolidone

Omqondofana:I-M-PYROL(R);1-Methyl-2-pyrrolidinone(99.5%, HyDry, Water≤50 ppm (nge-KF));1-Methyl-2-pyrrolidinone(99.5%, HyDry, nesisefo samangqamuzana, Amanzi≤50 ppm (ngu-KF)); Umkhiqizi we-N-Methyl-2-pyrrolidone;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT ( ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;N-Methyl-2-pyrrolidinone 872-50-4 NMP;1-METHYL-2-PYRROLIDINONE

I-CAS:872-50-4

MF:C5H9NO

MW:99.13

I-EINECS:212-828-1

Izigaba zomkhiqizo:I-NMP;Izinto zokusetshenziswa zamakhemikhali;I-UV/Vis);Izincibilikisi ze-GC Headspace;Izinto Ezincibilikayo zeGC;Izincibilikisi zezicelo ze-GC;Izinto Ezincibilikayo Zebanga Le-ACS;Ibanga le-ACS;Izincibilikisi Zebanga Le-ACS;Amakani Ensimbi Yekhabhoni AneMiluko ye-NPT;Izinsimbi Ezisindayo;Izincibilikisi ze-LC- I-ICP-MS;Ubuthi (ngaphandle kwezinsalela zezibulala-zinambuzane/izinsalela zezidakamizwa);Izicelo;Ukuhlaziywa Kweziphuzo;Izivimbeli zokwakha;C4 kuya ku-C8;I-Chemical Synthesis;Ukudla &;I-GC-MS Solvents;I-Heterocyclic Building Blocks;ICP-OES/-MS;Pyrrolidines; Ama-reagents for Inorganic Trace Analysis;Izinto Ezincibilikayo Zokuhlaziya I-Metal Speciation;Izincibilikisi Zokuhlaziya I-Speciation (LC-ICP-MS);I-Spectroscopy;Izinto Zokulandela Ukuhlaziya &;Imikhiqizo;Amabhodlela;Amabhodlela;Ama-Amine;Ama-Heterocycles;Izinto Eziyingxube Eziyingxube;I-Anhydrous Solvents; Isicelo;Amanye Amandla;Amabhodlela Engilazi Ye-Amber;Izinto Ezihlaziyayo;Okuhlaziya/I-Chromatography;I-CHROMASOLV Plus;Ama-Chromatography Reagents &;Electrolytes;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV;I-WPak Sciences Izincibilikisi ze-Organic;Izinto Ezincibilikayo Eziyi-Semi-Bulk;Amabhodlela e-Solvent;Izinketho zokupakisha ze-Solvent;I-UHPLC Solvents (CHROMASOLV);I-NMR;Ibanga leSpectrophotometric;Izincibilikisi zeSpectrophotometric;Izincibilikisi zeSpectroscopy (IR;Iziqukathi Ezibuyiselwayo;Amabhodlela aQinisekile/Ophawu;I-Solrovents;Bioventes; ;Uqinisekile/uqinisile?Amabhodlela;872-50-4;bc0001

Ifayela le-Mol:872-50-4.mol

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-Pyrrolidone Chemical Properties

Iphoyinti lokuncibilika	-24 °C (ukukhanya)
Iphuzu elibilayo	202 °C (okhanyisiwe) 81-82 °C/10 mmHg (okhanyisiwe)
ukuminyana	1.028 g/mL ku-25 °C (okhanyisiwe)
ukuminyana komhwamuko	3.4 (vs air)
umfutho womhwamuko	0.29 mm Hg ( 20 °C)
inkomba ye-refractive	n20/D 1.479
Fp	187 °F
izinga lokushisa lokugcina.	Gcina ku +5°C kuya +30°C.
ukuncibilika	i-ethanol: miscible0.1ML/mL, icacile, ayinambala (10%, v/v)
ifomu	Uketshezi
pka	-0.41±0.20(Kubikezelwe)
umbala	≤20(APHA)
PH	8.5-10.0 (100g/l, H2O, 20℃)
Iphunga	Iphunga elincane le-amine
PH Ububanzi	7.7 - 8.0
umkhawulo wokuqhuma	1.3-9.5%(V)
Ukuncibilika kwamanzi	>=10 g/100 mL ku-20 ºC
Kuyazwela	I-Hygroscopic
λ ubuningi	283nm(MeOH)(lit.)
I-Merck	14,6117
I-BRN	106420
Ukuzinza:	Izinzile, kodwa iyabola lapho uchayeka ekukhanyeni.Okuvuthayo.Akuhambisani nama-oxidizing agents aqinile, ama-acids aqinile, ama-ejenti okunciphisa, izisekelo.
I-InChIKey	I-SECXISVLQFMRJM-UHFFFAOYSA-N
I-LogP	-0.46 ngo-25℃
Ireferensi ye-CAS Database	872-50-4(CAS DataBase Reference)
I-NIST Chemistry Reference	I-2-Pyrrolidinone, i-1-methyl-(872-50-4)
I-EPA Substance Registry System	I-N-Methyl-2-pyrrolidone (872-50-4)

Ulwazi Lokuphepha

Amakhodi Wengozi	T,Xi
Izitatimende Zobungozi	45-65-36/38-36/37/38-61-10-46
Izitatimende Zokuphepha	41-45-53-62-26
I-WGK Germany	1
I-RTECS	UY5790000
F	3-8-10
I-Autoignition Temperature	518 °F
I-TSCA	Y
Ikhodi ye-HS	2933199090
Idatha Yezinto Eziyingozi	872-50-4(Idatha Yezinto Eziyingozi)
Ubuthi	I-LD50 ngomlomo kuNogwaja: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg

Ukusetshenziswa Pyrrolidone kanye Synthesis

Chemical Properties	I-N-Methyl-2-pyrrolidone iwuketshezi olukhanyayo olukhanyayo oluphuzi olukhanyayo olunephunga elincane le-ammonia.I-N-Methyl-2-pyrrolidone ixubene ngokuphelele namanzi.Incibilika kakhulu kuma-alcohols aphansi, ama-ketones aphansi, i-ether, i-ethyl acetate, i-chloroform, ne-benzene futhi inyibilika ngokulingene kuma-aliphatic hydrocarbon.I-N-Methyl-2-pyrrolidone i-hygroscopic kakhulu, izinzile ngokwekhemikhali, ayigqwali ibhekise ku-carbon steel ne-aluminium, futhi yonakalisa kancane ukuya kwikhopha.Inonamathela kancane, ikhemikhali eqinile kanye nokuzinza kwe-thermal, i-polarity ephezulu, nokuguquguquka okuphansi.Lo mkhiqizo unobuthi obuncane, futhi umkhawulo wawo wokugxilisa ingqondo ovunyelwe emoyeni ngu-100ppm. I-N-Methyl-2-pyrrolidone iyi-solvent esetshenziswa ezimbonini ezihlukahlukene kanye nezinhlelo zokusebenza, ezifana nokususwa kwepende ne-coating, ukucutshungulwa kwe-petrochemical, ukumbozwa kwepulasitiki yobunjiniyela, amakhemikhali ezolimo, ukuhlanza ngogesi kanye nokuhlanza izimboni / zasekhaya.
Isebenzisa	I-N-Methyl-2-pyrrolidone (NMP) iyi-solvent ye-polar aprotic enezinzuzo zobuthi obuphansi, indawo yokubilisa ephezulu, i-solvency evelele, ukukhetha okuqinile nokuzinza okuhle.Isetshenziswa kabanzi ekuhlanzeni ukukhishwa kwe-hydrocarbon enephunga elimnandi, i-acetylene, i-olefins, nama-diolefin. Isetshenziswa ekuhlanzeni izimboni, futhi isebenza njengesithako ekukhiqizeni izibulala-zinambuzane, amapulasitiki obunjiniyela, okokunamathela, imicu yokwenziwa, namasekethe ahlanganisiwe. Ingasetshenziswa futhi njengesihlanzi sezimboni, i-dispersant, idayi, i-lubricant kanye ne-antifreeze. I-N-Methyl-2-pyrrolidone iyi-solvent enhle kakhulu, esetshenziswa kabanzi ekukhishweni kwe-aromatics, ukucwenga uwoyela wokugcoba, ukucebisa i-acetylene, ukuhlukaniswa kwe-butadiene kanye ne-synthesis gas desulfurization. Isetshenziselwa i-gas desulfurization, ukucwenga uwoyela wokugcoba, i-lubricating oil antifreeze, i-olefin extraction, nanjenge-solvent ye-polymerization yobunjiniyela obungancibiliki. Ingasetshenziswa ku-herbicide, ukuhlanza izinto zokufakelwa, amathuluzi anemba embonini ye-semiconductor namabhodi wesekethe, ukuvuselela i-PVC exhaust, njengesihlanzi, isithasiselo sikadayi kanye ne-ejenti ehlakazayo. Isetshenziswa kuma-mediums ukusabela kwe-polymerization njengamapulasitiki wobunjiniyela kanye ne-aramid fiber. I-N-Methyl-2-pyrrolidone isetshenziswa njenge-polyvinylidene fluoride solvent kanye nezinto ezisizayo ze-electrode kumabhethri e-lithium ion. izinga eliphezulu lokuhlanzeka lokutholwa kwe-ICP-MS. Okwe-peptide synthesis.
ubuthi	I-Oral (mus)LD50:5130 mg/kg;Ezomlomo (igundane)LD50:3914 mg/kg;I-Dermal (rbt)LD50:8000 mg/kg.
Ukulahlwa kwemfucuza	Xhumana nemithetho yezwe, yendawo noma kazwelonke ukuze uthole ukuchithwa okufanele.Ukulahlwa kufanele kwenziwe ngokwemithethonqubo esemthethweni.Amanzi, uma kunesidingo ngama-agent okuhlanza.
isitoreji	I-N-Methyl-2-pyrrolidone i-hygroscopic (ithatha umswakama) kodwa izinzile ngaphansi kwezimo ezivamile.Izosabela ngobudlova ngezixube eziqinile ezifana ne-hydrogen peroxide, i-nitric acid, i-sulfuric acid, njll. Imikhiqizo eyinhloko yokubola ikhiqiza i-carbon monoxide ne-nitrogen oxide fumes.Ukuchayeka ngokweqile noma ukuchitheka kwegazi kufanele kugwenywe njengendaba yomkhuba omuhle.I-Lyondell Chemical Company incoma ukugqoka amagilavu e-butyl uma usebenzisa i-N-Methyl-2-pyrrolidone.I-N-Methyl-2-pyrrolidone kufanele igcinwe kunsimbi ehlanzekile, ene-phenolic-lined mild mild or drums.I-Teflon®1 ne-Kalrez®1 kukhonjiswe njengezisetshenziswa ezifanele ze-gasket.Sicela ubuyekeze i-MSDS ngaphambi kokuphatha.
Incazelo	I-N-Methyl-2-pyrrolidone iyi-solvent ye-aprotic enezinhlobonhlobo zezicelo: ukucutshungulwa kwe-petrochemical, i-surface coating, odayi nama-pigments, izinhlanganisela zokuhlanza ezimbonini nezasekhaya, kanye nokwakhiwa kwezolimo kanye nemithi.Ngokuyinhloko iyacasula, kodwa futhi ibangele izimo ezimbalwa zokuthinta i-dermatitis enkampanini encane ye-electrotechnical.
Chemical Properties	I-N-Methyl-2-pyrrolidone iwuketshezi olungenambala noma oluphuzi olukhanyayo olunephunga le-amine.Ingabhekana nenani lokusabela kwamakhemikhali nakuba yamukelwa njengesinyibilikisi esizinzile.Imelana ne-hydrolysis ngaphansi kwezimo ezingathathi hlangothi, kodwa i-asidi eqinile noma ukwelashwa kwesisekelo kuholela ekuvulekeni kwendandatho ku-4-methyl aminobutyric acid.I-N-Methyl-2-pyrrolidone ingancishiswa ibe yi-1-methyl pyrrolidine nge-borohydride.Ukwelashwa ngama-chlorinating agents kuholela ekwakhekeni kwe-amide, okumaphakathi okungase kufakwe okunye esikhundleni, kuyilapho ukwelashwa nge-amyl nitrate kuveza i-nitrate.I-Olefins ingangezwa endaweni ye-3 ngokwelashwa kuqala nge-oxalic esters, bese nge-aldehyes efanelekile (uHort no-Anderson 1982).
Isebenzisa	I-N-Methyl-2-pyrrolidone iyi-solvent ye-polar esetshenziswa ku-organic chemistry kanye ne-polymer chemistry.Izicelo zesilinganiso esikhulu zihlanganisa ukutholwa nokuhlanzwa kwama-acetylenes, ama-olefin, nama-diolefin, ukuhlanzwa kwegesi, nokukhipha ama-aromatics kusuka ku-feedstocks.I-N-Methyl-2-pyrrolidone iyincibilikiseli yezimboni enemisebenzi eminingi.I-NMP okwamanje igunyazelwe ukusetshenziswa emithini yezilwane kuphela.Ukunqunywa kwesimo kanye nokumenyezelwa kwe-NMP egundaneni kuzoba nomthelela ekuqondeni ubuthi baleli khemikhali yangaphandle okungenzeka umuntu achayeke kuyo ngamanani akhulayo.
Isebenzisa	I-solvent yama-resin aphezulu okushisa;ukucutshungulwa kwe-petrochemical, embonini yokwenziwa kwe-microelectronics, odayi nezingulube, izinhlanganisela zokuhlanza ezimbonini nezasekhaya;ukwakhiwa kwezolimo kanye nemithi
Isebenzisa	I-N-Methyl-2-pyrrolidone, iwusizo ku-spectrophotometry, i-chromatography kanye nokutholwa kwe-ICP-MS.
Incazelo	I-ChEBI: Ilungu lesigaba se-pyrrolidine-2-ones okuyi-pyrrolidin-2-one lapho i-hydrogen exhunywe ku-nitrogen ithathelwa indawo yiqembu le-methyl.
Izindlela Zokukhiqiza	I-N-Methyl-2-pyrrolidone ikhiqizwa ukusabela kwe-buytrolactone nge-methylamine (Hawley 1977).Ezinye izinqubo zihlanganisa ukulungiswa nge-hydrogenation yezixazululo ze-maleic noma i-succinic acid nge-methylamine (uHort no-Anderson 1982).Abakhiqizi baleli khemikhali bahlanganisa i-Lachat Chemical, Inc, Mequon, Wisconsin kanye ne-GAF Corporation, e-Covert City, eCalifornia.
Izithenjwa ze-Synthesis	Izincwadi zeTetrahedron, 24, p.1323, 1983I-DOI: 10.1016/S0040-4039(00)81646-9
Incazelo evamile	I-N-Methyl-2-Pyrrolidone (NMP) iyi-solvent enamandla, ene-aprotic ene-solvency ephezulu, nokuntengantenga okuphansi.Leli phuzu elingenambala, elibilisa phezulu, elikhanyayo eliphakeme kanye noketshezi olunomfutho womoya ophansi luphethe iphunga elithambile elifana ne-amine.I-NMP inokuqina okuphezulu kwamakhemikhali nokushisayo futhi ixubana ngokuphelele namanzi kuwo wonke amazinga okushisa.I-NMP ingasebenza njenge-co-solvent ngamanzi, utshwala, ama-glycol ethers, ama-ketones, nama-hydrocarbon anephunga elimnandi/i-chlorinated.I-NMP iyakwazi ukugaywa kabusha nge-distillation futhi i-biodegradable kalula.I-NMP ayitholakali ohlwini Lwezinto Ezingcolisa Umoya Eziyingozi (ama-HAP) zoMthetho Izichibiyelo Zomthetho Ohlanzekile Ka-1990.
Ukusabela Komoya Namanzi	Incibilika emanzini.
Iphrofayela Yokuphinda Isebenze	Le amine iyisizinda samakhemikhali esithambile kakhulu.I-N-Methyl-2-pyrrolidone ivamise ukwenza ama-asidi angasebenzi ukuze akhe usawoti kanye namanzi.Inani lokushisa eliguquguqukayo imvukuzane ngayinye ye-amine ku-neutralization lizimele kakhulu kumandla e-amine njengesisekelo.Ama-amine angase angahambelani nama-isocyanate, ama-halogenated organics, ama-peroxides, ama-phenols (ama-acidic), ama-epoxide, ama-anhydrides, nama-asidi halide.I-hydrogen eyigesi evuthayo ikhiqizwa ama-amine ehlanganiswe nezinto ezinciphisa amandla, njengama-hydrides.
Ingozi	Isikhumba esinzima kanye nokucasula kwamehlo.Umkhawulo weziqhumane-wawo ngu-2.2–12.2%.
Ingozi Yezempilo	Ukuhogela umoya oshisayo kungacasula ikhala nomphimbo.Ukungeniswa kubangela ukucasuka komlomo nesisu.Ukuthintana namehlo kubangela ukucasuka.Ukuthinta isikhumba okuphindaphindiwe kanye nesikhathi eside kuveza ukucasuka okuncane, okudlulayo.
Ingozi Yomlilo	Izingozi Ezikhethekile Zemikhiqizo Evuthayo: Ama-oxide anobuthi e-nitrogen angase akheke emlilweni.
Ukuvutha nokugqama	Okungashi
Ukusetshenziswa kwezimboni	I-1) I-N-Methyl-2-pyrrolidone isetshenziswa njenge-solvent ye-dipolalar aprotic ejwayelekile, ezinzile futhi engasebenzi; 2) ukukhishwa kwama-hydrocarbon anephunga elimnandi emafutheni okugcoba; 3) ukususwa kwe-carbon dioxide kumajeneretha e-ammonia; 4) njenge-solvent yokusabela kwe-polymerization nama-polymers; 5) njenge-stripper kapende; 6) ukwakhiwa kwezibulala-zinambuzane (USEPA 1985). Okunye ukusetshenziswa okungezona okwezimboni kwe-N-Methyl-2-pyrrolidone kusekelwe ezintweni zayo njenge-solvent ehlukanisayo efanele izifundo zamakhemikhali e-electrochemical kanye namakhemikhali omzimba (Langan noSalman 1987).Izinhlelo zemithi zisebenzisa izakhiwo ze-N-Methyl-2-pyrrolidone njengesithuthukisi sokungena ukuze kudluliselwe izinto ngokushesha esikhumbeni (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).I-N-Methyl-2-pyrrolidone igunyazwe njengesinyibilikisi sokufaka isicelo se-slimicide ezintweni zokupakisha ukudla (USDA 1986).
Xhumana nama-allergener	I-N-Methyl-2-pyrrolidone iyi-solvent ye-aprotic enezinhlobonhlobo zezicelo: ukucutshungulwa kwe-petrochemical, i-surface coating, odayi nama-pigments, izinhlanganisela zokuhlanza ezimbonini nezasekhaya, kanye nokwakhiwa kwezolimo kanye nemithi.Ngokuyinhloko iyacasula, kodwa ingabangela i-dermatitis enzima ngenxa yokuxhumana isikhathi eside.
Iphrofayela Yokuphepha	Ubuthi ngomzila we-intravenous.Inobuthi obumaphakathi ngokumunca kanye nemizila ye-intraperitoneal.Ubuthi obuncane ngokuthinta isikhumba.I-teratogen yokuhlola.Imiphumela yokuhlola yokuzala.Idatha yokuguquguquka ibikiwe.Iyasha lapho ichayeke ekushiseni, elangabini elivulekile, noma izikhuthazi-moya ezinamandla.Ukulwa nomlilo, sebenzisa igwebu, i-CO2, ikhemikhali eyomile.Uma ishiselwa ukuze ibole ikhipha intuthu enobuthi ye-NOx.
I-Carcinogenicity	Amagundane atholakale ku-N-Methyl-2-pyrrolidone vapor ku-0, 0.04, noma i-0.4 mg / L ye-6 h / usuku, izinsuku ezingu-5 / isonto iminyaka engu-2. Amagundane abesilisa ku-0.4 mg / L abonise ukunciphisa kancane isisindo somzimba.Ayikho imiphumela enobuthi enciphisa impilo noma ye-carcinogenic ebonwe kumagundane adalulwe iminyaka engu-2 ku-0.04 noma i-0.4mg/L ye-N-Methyl-2-pyrrolidone.Ngomzila we-dermal, iqembu lamagundane angu-32 lithole umthamo wokuqalisa we-25mg we-N-Methyl-2-pyrrolidone elandelwa amaviki angu-2 kamuva ngokusetshenziswa komgqugquzeli we-tumor phorbol myristate acetate, kathathu ngesonto, ngaphezu kwamaviki angu-25.I-Dimethylcarbamoyl chloride ne-dimethylbenzanthracene zisebenze njengezilawuli ezinhle.Nakuba iqembu le-N-Methyl-2-pyrrolidone lalinamathumba esikhumba amathathu, le mpendulo ayizange ibhekwe njengebalulekile uma iqhathaniswa neyokulawula okuhle.
Indlela ye-metabolic	Amagundane anikezwa umsakazo obhalwe ukuthi N-methyl-2- pyrrolidinone (NMP), futhi umzila omkhulu wokukhishwa kwamagundane ngomchamo.I-metabolite enkulu, emele i-70-75% yomthamo olawulwayo, i-4-(methylamino)butenoic acid.Lo mkhiqizo ongaqinile ongaphelele ungase wakheke ekukhishweni kwamanzi, futhi iqembu le-hydroxyl lingase libe khona ku-metabolite ngaphambi kwe-acid hydrolysis.
I-Metabolism	Amagundane abesilisa be-Sprague-Dawley anikezwe umjovo owodwa we-intraperitoneal (45 mg / kg) we-radiolabeled 1 -methyl-2-pyrrolidone.Amazinga e-plasma e-radioactivity kanye nenhlanganisela aqashwe amahora ayisithupha futhi imiphumela yaphakamisa isigaba sokusabalalisa esisheshayo esalandelwa isigaba sokuqeda kancane.Inani elikhulu lelebula lakhishwa emchamweni phakathi kwamahora angu-12 futhi labalelwa cishe u-75% wethamo elilebuli.Amahora angamashumi amabili nane ngemva komthamo, ukuphumela obala (umchamo) kwakucishe kube ngu-80% womthamo.Zombili izinhlobo ezibhalwe indandatho ne-methyl zasetshenziswa, kanye nazo zombili [¹⁴C]- kanye ne-[3H]-ebhalwe ukuthi l-methyl-2-pyrrolidone.Izilinganiso zokuqala ezilebulwe zagcinwa phakathi namahora angu-6 okuqala ngemva komthamo.Ngemuva kwamahora ayi-6, isibindi namathumbu kwatholakala ukuthi kuqukethe ukunqwabelana okuphezulu kakhulu kwe-radioactivity, cishe u-2-4% womthamo.I-radioactivity encane yaphawulwa ku-bile noma emoyeni ophefumulayo.Ukusebenza okuphezulu kwe-chromatography ye-liquid yomchamo kubonise ukuba khona kwe-metabolites eyodwa enkulu namancane amabili.I-metabolite enkulu (i-70-75% yomthamo osetshenziswayo we-radioactive) yahlaziywa nge-liquid chromatography-mass spectrometry kanye ne-gas chromatography-mass spectrometry futhi yahlongozwa ukuthi ibe yi-3- noma i-5-hydroxy-l-methyl-2-pyrrolidone (Wells). 1987).
Izindlela Zokuhlanza	Yomisa i-pyrrolidone ngokukhipha amanzi njenge-azeotrope ye-benzene.I-distil nge-fractionally at 10 torr ngokusebenzisa ikholomu engu-100-cm egcwele ama-helice engilazi.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] I-hydrochloride ine-m 86-88o (kusuka ku-EtOH noma i-Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]