Imikhiqizo
Methyl d - (-) - 4-hydroxy-phenylglyciate; Case No.: 37763-23-8
Ama-Synonyms: I-BengeneACetacid, α-Amino-4-Hydroxy-, Methyl Ester, (R); D - (-) - α-amino-α- (4-hydroxyphenyl) acetate; i-methyl (r) -amino (4-hydroidoxyphenyl) acetate;
Impahla yamakhemikhali ye-methyl d - (-) - 4-hydroxy-phenylglyciate
● Ingcindezi ye-Vapor: 6.03E-05mmhg ngo-25 ° C
● Inkomba evulekayo: 1.57
● Iphuzu elibilayo: 335.7 ° C ku-760 mmhg
● I-PKA: 9.74 ± 0.26 (Ebikezelwe)
● Iphuzu le-Flash: 156.9 ° C
● PSA: 72.55000
● Hlensity: 1.248 g / cm3
● logp: 1.26530
● Isitoreji Temp.:
● I-Solubity.:DMSO (kancane), i-Ethanol (kancane, i-Sonid), Methanol (kancane)
● xLogp3: 0.5
● I-Hydrogen Bond Donor Count: 2
● Isibalo sakwama-Hydrogen Bond samukelwa: 4
● I-rotatable bond count: 3
● Isisindo esiqondile: 181.07389321
● Isibalo se-athomu esindayo: 13
● Ukunkimbanisa: 176
Imininingwane Ephelile
● pictograph (s):
● Amakhodi Avikelekayo:
-Sizayo
● Ukumamatheka kwe-can: coc (= o) c (C1 = cc = c (c = c1) o) n
● Sebenzisa: I-methyl d - (-) - 4-hydroxy-phenylglyciate ilusizo ku-synthesis (+) - i-radicamine B. futhi, isetshenziselwa ukulungiswa kwe-amoxicillin.
Isingeniso Esinemininingwane
D-4-Hydroxypeyyllycine Methyl Ester, eyaziwa nangokuthi i-D-HPG Methyl Ester noma i-D-4-Hydroxyphenyllycine Methyl Ester hydrochloride, iyindawo yamakhemikhali ngefomula ka-formula c9h11no3 kanye ne-molar mass ka-181.19 g / mol. Yindlela ye-methyl ester ye-D-4-Hydroxyphenyllycine.d-4-hydroxyphenyllyline methyl ester yingxenye ye-chiral enesakhiwo esiyingqayizivele esifaka indandatho ye-phenyl kanye ne-amio acid backbone. Ihlelwe ngezicelo ezahlukahlukene, kufaka phakathi ukusetshenziswa kwayo njenge-board block ku-organic synthesis kanye nentuthuko yezemithi.Ukusebenza okubalulekile kwe-D-4-hydroxyphenyllycine methyl ester kuyinto ebandakanyeka emikhandlu. Ingasebenza njengengqayizivele ekukhiqizweni kwezidakamizwa ezinjenge-β-lactam antibiotic, ama-analog e-peptide, nezinye izinhlanganisela ezi-bioactive. Ukufakwa kwalo ku-molecule yale mishanguzo kungaletha izakhiwo ezizuzisayo noma ukuthuthukisa umsebenzi wazo. Kepha-ke, i-D-4-hydroxyphenyllyslycine methyl ester methyl ester ikhombisa izakhiwo zokwelapha zodwa. Kufundwe i-antioxidant yayo, anti-inflammatory, nemiphumela emihle. Lezi zakhiwo zikwenza kube yisihloko sentshisekelo ekuthuthukisweni kwezidakamizwa zezimo ezahlukahlukene zezokwelapha, kufaka phakathi izifo ze-neurodegenerative.Umthylyphonyllycine Methyl Ester yindawo yamakhemikhali enezicelo zokuhlanganiswa kwemithi kanye nemiphumela yokwelapha engaba khona. Isakhiwo saso esiyingqayizivele kanye nemvelo ye-chibi yenza ibaluleke njengebhulokhi yokwakha yokuthuthuka kwezidakamizwa, futhi imisebenzi yayo yemvelo ekhonjisiwe yasikisela amandla awo ezicelo ezahlukahlukene zezokwelapha.
Isicelo
I-methyl d - (-) - 4-hydroxy-phenylglycinate inokusetshenziswa okuningi okungaba khona kanye nezicelo:
Ucwaningo lwezemithi:Le compact ingasetshenziswa njengebhulokhi yokwakha ekuhlanganiseni kwamakhompiyutha ahlukahlukene emithi. Kusebenza njengomphakathi wokuhlanganiswa kwezidakamizwa kanye namakhompiyutha asebenzayo ngokwemvelo.
Isinqumo se-chirali:I-Compound's Chirality yenza kube wusizo ezifundweni zokuxazululwa kweChiral. Ingasetshenziswa ukuhlukanisa ukuxubeka kobuhlanga kuma-enantiomers abo.
Synthesis we-asymmetric:I-methyl d - (-) - 4-hydroxy-phenylglyciate ingasetshenziswa njenge-chiral auxiliary in asymmetric synthesis, inika amandla ukuhlanganiswa kwama-compounds anamandla kakhulu.
Ukuthuthukiswa Kwezidakamizwa:Ukwakheka kwezakhiwo nezakhiwo zenza kube umuntu ongaba okhethwayo wokuthuthukiswa kwezidakamizwa.Ingashintshwa ukuze athuthukise umsebenzi wawo wekhemisi noma athuthukise izakhiwo zawo ezinjengezidakamizwa.
Kubalulekile ukuqaphela ukuthi ukusetshenziswa okuthile kwe-methyl d - (-) - 4-hydroxy-phenylglycate kuzoncika ocwaningweni olufunayo noma kuhlelo lokusebenza, futhi kuqhubeke uphenyo noma ukubonisana nochwepheshe kungadingeka.
