Imikhiqizo
Dicyclohexylccarbodiimiimiimide; I-CAS No.: 538-75-0
Amanyanjana: DCCD; DICYClohexylcarbodiimiimiimiimiimiimiimide
Impahla yamakhemikhali yeDicyclohexylcArbodiimiimiimiimide
● Ukubukeka / umbala: angenambala aqinile
● Ingcindezi ye-Vapor: 1.044-1.15PA ngo-20-25 ℃
● Iphoyinti elincibilikayo: 34-35 ° C (Lit.)
● Inkomba evulekayo: N20 / D 1.48
● Iphuzu elibilayo: 277 ° C ku-760 mmhg
● iphuzu le-flash: 113.1 ° C
● Psa:24.72000
● Hlensity: 1.06 g / cm3
● logp: 3.82570
● Isitoreji se-temp.:store ku-rt.
● I-SENTITE.:moiture ebucayi
● I-Solubity.:methylene Chloride: 0.1 g / ML, Sula, Ungenamibala
● Amanzi e-solubity.:reathiour
● xLogp3: 4.7
● I-Hydrogen Bond Donor Count: 0
● Ukubalwa Kwama-Hydrogen Bond kwamukelwa: 2
● I-rotatable Bond Count: 2
● Isisindo esiqondile: 206.178298710
● Isibalo se-athomu esindayo: 15
● Ukunkimbana: 201
● Ilebuli ye-DATS DOT: ubuthi
Imininingwane Ephelile
● pictograph (s):
T,
I-XN
● Amakhodi Anobungozi: t, xn, t +
● Izitatimende: 23/15/15-344-40-43-41-36 / 38-21-24-22-62-37 / 38-10-27 / 38-38-20 / 38
● Izitatimende zokuphepha: 26-36 / 37/37/37-4-45-41-24-37 / 39-24 / 25-36-16-53-28
-Sizayo
Amakilasi Amakhemikhali:Ama-Nitrogen Compounds -> Amanye amakhompiyutha we-nitrogen
Ukumamatheka kwe-canonical:I-C1CCC (CC1) N = C = NC2CCCCCC2
Incazelo:I-DICYDOHEXYL Carbodiimide isetshenziswa kumakhemikhali we-peppide njenge-realent ehlanganisiwe. Kokubili kuyacasula futhi kuzwakala i-sensitizer, futhi kwangenza ukuthintwa kwe-dermatitis kosokhemisi nakubakhemisi.
Sebenzisa:Ekuhlanganiseni kwama-peptides. Lo mkhiqizo usetshenziswe ikakhulukazi ku-ampikacin, ama-dehydrants we-glutathione, kanye nase-synthesis we-anhydride anhydride, i-Aldehyde, iKetone, isocyanate; Lapho isetshenziswa njenge-ejenti evuthayo emzimbeni, iphendula nge-daicyclohexylurea ngokusabela kwesikhashana ngaphansi kokushisa okujwayelekile. Lo mkhiqizo ungasetshenziswa futhi ku-synthesis we-peptide ne-nucleic acid. Kulula ukusebenzisa lo mkhiqizo ukuze usabele nge-compact yamahhala ye-carpobox ne-amino-group ibe yi-peptide. Lo mkhiqizo usetshenziswa kabanzi kwezokwelapha, ezempilo, ukwakheka nemikhiqizo yemvelo, nakwamanye amasimu okwenziwa. N, N'-DICYClohexylcArbodiimiimiimiiimide i-carbodiimide esetshenziselwa ama-amino acid ngesikhathi sokuhlanganiswa kwe-peptide. N,N'-Dicyclohexylcarbodiimide is used as a dehydrating agent for the preparation of amides, ketones , nitriles as well as in the inversion and esterification of secondary alcohols. I-DicyClohexylCarbodiimiimiimiiimide isetshenziswa njenge-ejenti yokuphelelwa ngamandla emazingeni okushisa asekamelweni ngemuva kwesikhathi esifushane sokuphendula, ngemuva komkhiqizo wokuphendula uyi-DIYICYLexLexLexLexLexLexLeslure. Umkhiqizo muncane kakhulu i-solubity ku-organic solvent, ukuze ukuhlukaniswa okulula komkhiqizo wokuphendula.
Isingeniso Esinemininingwane
Dicyclohexylcarbodiimide (DCC) i-reagent esetshenziswa kakhulu ekuhlanganiseni kwe-organic. Kuqinile okumhlophe okungekho emthethweni emanzini futhi kuyancibilika ku-solvents yezinto eziphilayo njenge-ethylo acetate ne-dichloromethane.
I-DCC isetshenziswa ngokuyinhloko njenge-ejenti ehlanganayo ekuhlanganiseni kwe-peptide nokunye ukusabela okubandakanya ukwakheka kwamabhondi amide. Ikhuthaza ukubuyiselwa kwama-carboxylic acid ngama-amorines, okuholela ekwakhekeni kwezingalo. Ikufeza lokhu ngokwenza kusebenze iqembu le-carboxylic acid futhi kusiza ukuhlaselwa kwe-nucleophilic kwe-anine kwikhabhoni evuliwe ye-carbonyl.
Ngokungeziwe ku-peptide synthesis, i-DCC nayo isetshenziswa ezindaweni ezahlukahlukene eziphilayo, njengokuchazwa kokuqonda kanye nokusabela. Ingaqashwa ukuze ithole ama-esters kusuka kuma-carboxylic acid kanye notshwala, futhi ukuguqula ama-carboxylic acid acid acid (njengama-chloride acid, anhydrides anhydrides, futhi aculiwe ama-esters) abe yi-anaides.
I-DCC yaziwa ngokusebenza kwayo okuphezulu ekuthuthukiseni ukwakheka kwesibopho se-Amide kanye nokuhambisana kwayo ngamaqembu ahlukahlukene asebenzayo. Kodwa-ke, kubhekwa futhi ukuthi kubucayi umswakama futhi kungabola kalula ekuchayweni kwamanzi noma umswakama ophezulu. Ngakho-ke, imvamisa iphathwa futhi igcinwe ngaphansi kwezimo ezine-anhydrous.
Kubalulekile ukuthatha izinyathelo zokuphepha ezidingekayo lapho usebenza ne-DCC, ngoba ingacasula esikhunjeni, emehlweni, kanye nohlelo lokuphefumula. Umoya omncane kanye nemishini yokuzivikela kufanele isetshenziswe ngesikhathi sokuphatha.
Isicelo
I-DICYCLEXYLCARBODIIMIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDINDI KWE-ORGANIC SYINTSSISISIS ORDERNETS OPROMENTSORY MOREPTION OREPTICE Nazi izinhlelo ezimbalwa eziphawuleka ze-DCC:
Synthide synthesis:I-DCC isetshenziswa kakhulu njenge-ejenti ehlanganayo ekuhlanganiseni kwe-peptide ukujoyina ama-amino acid ndawonye bese wenza izibopho ezimisiwe. Ikhuthaza ukusabela kokuvundiselwa phakathi kweqembu le-carboxyl ye-amino acid eyodwa neqembu le-amino lomunye, okuholela ekwakhekeni kwamabhondi ama-peptide.
Ukusabela kokuqonda:I-DCC ingasetshenziswa ukuguqula ama-carboxylic acid abe ama-esters ngokuwaphendula ngotshwala. Ekhoneni le-DCC, i-carboxylic acid icushiwe, ivumela ukuhlaselwa kwe-nucleophilic ngotshwala ukuze kwakheke i-ester. Lokhu kusabela kuwusizo ekuhlolweni kwama-esters ngezicelo ezahlukahlukene.
Ukusabela okuhlangenwe nakho:I-DCC ikwazi ukwenza lula ukuxhumana kwama-carboxylic acid, ama-chloride acid, i-anhydrides acid, futhi aculiwe ama-ester. Ivumela ukusabela phakathi kwe-carboxylic acid etholwa kanye ne-anine ukwakha ibhondi le-Amide. Lolu hlelo lokusebenza luthola ukusetshenziswa ku-synthesis of Amides, okubalulekile ezinhlelweni ezahlukahlukene zebhayoloji kanye namakhemikhali.
Ukusabela kwe-UGI:I-DCC ingasetshenziswa ekuphenduleni kwe-UGI, ukusabela okuningiliziwe okubandakanya ukuguquguquka kwe-amine, i-isocyanide, i-carbonyl compound, ne-acid. I-DCC isiza ekusebenzeni kweqembu le-carboxyl le-acid, likuvumela ukuba senze nge-anine futhi wakhe ibhondi le-Amide.
Ukuhlanganiswa kwezidakamizwa:I-DCC ivame ukuqashwa embonini yezemithi ukuze i-synthesis yabazongenela izidakamizwa kanye nezithako ezisebenzayo zemithi (API). Ukusetshenziswa kwayo ku-peptide synthesis, ukuphahlazeka, kanye nokunye ukuguquka okubalulekile kwenza kube yi-realent ebalulekile ekutholweni kwezidakamizwa nezinqubo zentuthuko.
Kuhle ukuqaphela ukuthi i-DCC inezinye izinhlelo zokusebenza eziningi ku-organic synthesis, kufaka phakathi ukwakheka kwe-umelovu, ama-carbamates, kanye nama-hydrazides. Ukuguquguquka kwayo kanye nokuhambisana namaqembu ahlukahlukene asebenzayo kwenza kube yithuluzi elibalulekile ebhokisini lamathuluzi lokwekhema kokwenziwa.
