Imikhiqizo
Di-terrt-butyl dicarbonate; Case No.: 24424-99-5
Amanyanjana: I-BIS (Tert-aboxycarbonyl) oxide; i-BOC (2) o CPD; I-BOC2O CPD; di-tert-butyl dicarbonate; di-tert-butyllicarbonate
Impahla yamakhemikhali ye-di-terrt-butyl dicarbonate
● Ukubukeka / umbala: mhlophe ku-off-mhlophe microcrystalline powder
● Ingcindezi ye-Vapor: 0.7mmhg ngo-25 ° C
● Iphuzu elincibilikayo: 22-24 ° C
● Inkomba evulekayo: 1.4090
● Iphuzu elibilayo: 235.8 ° C ku-760 mmhg
● I-Flash Point: 103.7 ° C
● Psa:I-61.83000
● Hlensity: 1.054 g / cm3
● logp: 2.87320
● Isitoreji Temp.:2-8
● I-SENTITE.:moiture ebucayi
● Amanzi e-solubility.:
● xLogp3: 2.7
● I-Hydrogen Bond Donor Count: 0
● Isibalo sakwamandla e-hydrogen
● I-Rotatable Bond Count: 6
● Isisindo esiqondile: 218.11542367
● Isibalo se-athomu esindayo: 15
● Ukuba yinkimbinkimbi: 218
Imininingwane Ephelile
● pictograph (s):
T, t +,
F, f +,
I-XI
● Amakhodi Avikela: T +, T, F, XI, F +
● Izitatimende: 11-19-26-36 / 37/38-43-10-40
● Izitatimende Zokuphepha: 16-26-28-36-36 / 37-45-7 / 9-37 / 39-24-36 / 37/39-33
-Sizayo
Amakilasi Amakhemikhali:Amanye amakilasi -> ama-ester, okunye
Ukumamatheka kwe-canonical:CC (C) (C) OC (= O) OC (= O) OC (c) (c) c
Sebenzisa:I-Di-Tert-Butyl Dicarbonate (BOC2O) iyindlela esetshenziswa kabanzi ye-reagent yokwethula amaqembu okuvikela e-peptide synthesis. Idlala indima ebalulekile ekuhlelweni kwe-6-acetyl-1,2,3,4-tetrahydropyridine ngokuphendula nge-2-piperidone. Kusebenza njengeqembu elivikelayo elisetshenziswa e-Sylide Peptide Synthesis.
Isingeniso Esinemininingwane
Di-terrt-butyl dicarbonatei-realent esetshenziswa ekuhlolweni kwe-organic. Yaziwa nangokuthi i-T-BOC Anhydride noma i-BOC Anhydride. Kuvame ukusetshenziselwa ukuvikela amaqembu asebenza ngezikhathi ngesikhathi sokuphendula kwamakhemikhali. I-Di-Tert-Butyl Dicarbonate iphendula nge-ANYNESS ukuze kwakhiwe ama-Carbamate Derivatives, enikeza ukuvikelwa kwesikhashana kweqembu le-Amine. Lapho ukusabela okufiselekayo sekuqediwe, iqembu le-carbamate lingasuswa kalula ukwelashwa nge-acid, lithela ukusebenza kwangempela kwe-anine. Leli isu eliwusizo lokushintsha amaqembu athile asebenzayo kuma-molecule aphilayo.
Isicelo
Ngaphezu kokuvikela amaqembu a-Amine, i-Di-Butyl Dicarbonate inezinye izinhlelo zokusebenza ezahlukahlukene ku-organic synthesis:
Ukuvikelwa kwamaqembu e-hydroxyl:I-Di-Tert-Butyl Dicarbonate ingasabela ngotshwala ukwakha ama-carbonates, ukuvikela iqembu le-hydroxyl. Iqembu le-carbonate lingasuswa kusetshenziswa izimo ezifanele, livumela ukuguqulwa okukhethiwe kwamanye amaqembu asebenzayo.
Ukusabela kwe-Carbondlation:I-Di-Tert-Butyl Dicarbonate ingasetshenziswa njengomthombo we-carbon monoxide ekuphendukeni kwe-carbondlation. Iphendula ngama-nucleophiles anjengemine, ama-alcohols, kanye nama-thiols ukwakha imikhiqizo ye-carbosted.
Ukulungiselela ama-chloride e-acid:Ukuphendula i-Di-ter-Butyl Dicarbonate nge-thionjoyl chloride noma i-oxalyll chloride iveza ama-chloride ahambisanayo we-acid. Ama-chlorides acid ahlukahlukene asetshenziswa ezinguquko ezinhlobonhlobo zezinguquko zokwenziwa.
Ukuhlanganiswa kwe-peptide yesigaba esiqinile:I-Di-Tert-Butyl Dicarbonate isetshenziswa kakhulu eziteshini zokuvikelwa kanye nokushunqiswa ku-sypteride yesigaba esijwayelekile. Isetshenziselwa ukuvikela ama-amino acid ngesikhathi sokwandiswa kwe-chain futhi asuse ukuvikela amaqembu ukudalula amaqembu e-Amino ngokuphendula okulandelayo okuhlanganisiwe.
Ukusabela kwe-polymerization:I-Di-Tert-Butyl Dicarbonate ingasebenza njenge-ejenti yokudluliswa kwe-chain ekuphendukeni kwe-polymerization. Kungasabela ngamaketanga akhulayo we-polymer, ukuqeda ukukhula kwawo noma ukukhiqiza izingosi ezintsha ezisebenzayo.
Lezi yizibonelo ezimbalwa nje zokusetshenziswa okuningi kwe-di-tert-butyl dicarbonate ku-organic synthesis. Ukusebenza kwayo okuhlukahlukene nokusebenziseka kalula kwenza kube yi-reagent ebalulekile ekuguqulweni kwamakhemikhali ahlukahlukene.
