I-Di-tert-butyl dicarbonate

Incazelo emfushane:

Igama Lomkhiqizo:I-Di-tert-butyl dicarbonate

Omqondofana:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, okuqinile/uketshezi

I-CAS:24424-99-5

MF:I-C10H18O5

MW:218.25

I-EINECS:246-240-1

Izigaba zomkhiqizo:Imithi Ephakathi;Ukuqala Izinto Ezingahluziwe & Okuphakathi;Okuphuma Ku-Amino Acid;Izinto Eziphilayo;Izinto Ezivikelayo ze-N;I-Biochemistry;I-Peptide Synthesis;Izinto Ezivikelayo & Zokukhipha Izakhi (zokwenziwa);Izinto Ezivikelayo (Peptide Synthesis);Ama-Reagents e-OligosanicCheridesi; Uchungechunge lwe-Boc-Amino acid;Izinto Ezisetshenziswayo Eziyingxube;DIBOC;1H-Inden-1-ol;bc0001;24424-99-5

Ifayela le-Mol:24424-99-5.mol

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-Di-tert-butyl dicarbonate Chemical Properties

Iphoyinti lokuncibilika	23 °C (okhanyisiwe)
Iphuzu elibilayo	56-57 °C/0.5 mmHg (okhanyisiwe)
ukuminyana	0.95 g/mL ku-25 °C (okhanyisiwe)
umfutho womhwamuko	3.85Pa ku-25℃
inkomba ye-refractive	n20/D 1.409(lit.)
Fp	99 °F
izinga lokushisa lokugcina.	2-8°C
ifomu	I-Crystalline Encibilika Ephansi Eqinile
umbala	Emhlophe
I-Gravity ethize	0.950
Ukuncibilika kwamanzi	Kuhlanganiswe ne-decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile kanye ne-dimethylformamide.Akuhambisani namanzi.
Kuyazwela	Kuyazwela Umswakama
I-BRN	1911173
I-InChIKey	I-DYHSDKLCOJIUFX-UHFFFAOYSA-N
I-LogP	1.87 ku-25℃
Ireferensi ye-CAS Database	24424-99-5(CAS DataBase Reference)
I-EPA Substance Registry System	I-Dicarbonic acid, i-bis(1,1-dimethylethyl) ester (24424-99-5)

Ulwazi Lokuphepha

Amakhodi Wengozi	T+,T,F,Xi,F+
Izitatimende Zobungozi	11-19-26-36/37/38-43-10-40
Izitatimende Zokuphepha	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
I-RIDADR	UN 2929 6.1/PG 1
I-WGK Germany	3
I-RTECS	HT0230000
F	4.4-10-21
I-Autoignition Temperature	460 °C
Inothi Lengozi	Okuvutha umlilo/Okucasulayo/Kunobuthi Kakhulu
I-TSCA	Yebo
I-HazardClass	6.1
PackingGroup	I
Ikhodi ye-HS	29209010
Ubuthi	I-LD50 ngomlomo kuNogwaja: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Ukusetshenziswa kwe-Di-tert-butyl dicarbonate kanye Nokuhlanganiswa

Chemical Properties	I-Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) iyikristalu engenambala ukuya kokumhlophe ukuya kokuphuzi, isisindo esiqinile noma uketshezi olucacile.Incibilika endaweni yokushisa yegumbi (mp=23°C).Ayiboli kulokhu noma amazinga okushisa aphakeme kancane.Isibonelo, ngokuvamile ihlanzwa ngokufakwa emanzini ngaphansi kwengcindezi encishisiwe emazingeni okushisa afika cishe ku-65°C.Emazingeni okushisa aphezulu izobola ibe yi-isobutene, i-t-butyl alcohol ne-carbon dioxide.
Isebenzisa	I-Di-tert-butyl dicarbonate (Boc2O) iyi-reagent esetshenziswa kakhulu ukwethula amaqembu avikelayo ekuhlanganiseni kwe-peptide.Idlala indima ebalulekile ekulungiseleleni i-6-acetyl-1,2,3,4-tetrahydropyridine ngokusabela nge-2-piperidone.Isebenza njengeqembu elivikelayo elisetshenziswa ekuhlanganiseni kwesigaba esiqinile se-peptide.
Ukulungiselela	Ukulungiswa kwe-Di-tert-butyl dicarbonate imi kanje:Kusixazululo sikasawoti we-monoester sodium kwengezwa u-2g we-N, i-N-dimethylformamide, i-1g ye-pyridine, i-1g ye-triethylamine, Ukupholisa kuya ku-5~0°C, i-60g diphosgene yayihamba kancane. i-dropwise engeziwe phakathi kwe-1.5h ye-dropwise eyengeziwe isiqediwe, ifudumele ekamelweni lokushisa (25°C), ifakwe amahora angu-2, ukusabela kwavunyelwa ukuma ngemva kokuhlunga, ukugeza isixazululo sezinto eziphilayo.Omiswe nge-anhydrous magnesium sulfate, isincibilikisi sahluzwa ngomfutho womoya ukuze sinikeze umkhiqizo ongahluziwe ongu-65~70g.Ngemuva kokupholisa nokucwebezela, ama-57-60g e-di-tert-butyl dicarbonate atholwe ngesivuno esingu-60-63%.
Incazelo	I-ChEBI: I-Di-tert-butyl dicarbonate iyi-acyclic carboxylic anhydride.Isebenza ngokuhlobene ne-dicarbonic acid.
Ukusabela	Ukusabela kwama-anilines afakwe esikhundleni se-Boc2O phambi kwenani le-stoichiometric le-4-dimethylaminopyridine (DMAP) ku-solvent engasebenzi (i-acetonitrile, i-dichloromethane, i-ethyl acetate, i-tetrahydrofuran, i-toluene) ekushiseni kwekamelo kuholela ku-aryl isocyanate cishe ngamanani angu-10 imiz. I-Di-tert-butyl dicarbonate kanye ne-4-(dimethylamino) pyridine iphinde yavakashelwa.Ukusabela kwabo ngama-amine notshwala
Incazelo evamile	Di-tert-butyl dicarbonate (Boc₂O) iyi-reagent esetshenziselwa kakhulu ukwethulwa kweqembu lokuvikela le-Boc ukuze kusebenze i-amine.Ibuye isetshenziswe njenge-ejenti eqeda amanzi emzimbeni kwezinye izimo zemvelo, ikakhulukazi ngama-carboxylic acid, amaqembu athile e-hydroxyl, noma nama-nitroalkanes ayisisekelo.
Ingozi	I-irritant engase ibangele ukulimala kwamehlo okubi;Ingabangela ukuzwela kwesikhumba;Kunobuthi kakhulu ngokuhogela
Ukuvutha nokugqama	Okuvutha umlilo
Izindlela Zokuhlanza	Ncibilikisa i-ester ngokushisisa ku-~35o, futhi uyidilize endaweni engenalutho.Uma i-IR ne-NMR ( 1810m 1765 cm-1 , ku-CCl4 1.50 singlet) iphakamisa ukungcola okukhulu kakhulu, bese ugeza ngevolumu elinganayo ye-H2O equkethe i-citric acid ukuze wenze ungqimba olunamanzi lube ne-asidi kancane, qoqa ungqimba lwe-organic bese ulomisa phezu kwe-anhydrous MgSO4 futhi uyichithe endaweni engenalutho.[UPapa et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] ELIVUTHA.