Imikhiqizo
I-4-hydroxy-d - (-) - 2-phenylglycine; Case No.: 22818-40-4
Ama-Synonyms: (R, S) -3HPG; I-4-hydroxyphenyllycine; . (+ -) - I-Isomer; 4-hydroxypeyllycine, 2,4-dimethylbenzenfonate, (R) -Isomer; . 25842; UK-25842
Impahla yamakhemikhali ye-D (-) - 4-hydroxyphenyllycine
● Ukubukeka / umbala: off-white powder
● Ingcindezi ye-Vapor: 0.000272mmhg ngo-25 ° C
● Iphuzu elincibilikayo: 240 ° C (Dec.) (Lit.)
● Inkomba yokuphinda uyisebenzise: -158 ° (c = 1, 1mol / l hcl)
● Iphuzu elibilayo: 365.8 ° C ku-760 mmhg
● I-PKA: 2.15 ± 0.10 (Ebikezelwe)
● Iphuzu le-Flash: 175 ° C
● PSA: 83.55000
● Hlensity: 1.396 g / cm3
● logp: 1.17690
● Isitoreji Temp.:Store ngezansi + 30 ° C.
● I-Solubity.:5G/L
● Amanzi e-Solubity.:5 G / L (20 ºC)
● xLogp3: -2.1
● I-Hydrogen Bond Donor Count: 3
● Isibalo sakwama-Hydrogen Bond samukelwa: 4
● I-rotatable Bond Count: 2
● Isisindo esiqondile: 167.058243149
● Isibalo se-athomu esindayo: 12
● Ukuba yinkimbinkimbi: 164
Imininingwane Ephelile
● pictograph (s):
Xi
● Amakhodi Ayingozi: XI
● Izitatimende: 36/37/38
● Izitatimende zokuphepha: 26-36-24 / 25
-Sizayo
● Ukumamatheka kwe-canonical: C1 = cc (= cc = c1c (c (= o) o) n) o) o) o) o
● I-isomeric ukumamatheka: C1 = CC (= cc = c1 [c @ h] (c (= o) o) n) o)
● Sebenzisa: 4-hydroxy-d - (-) - 2-phenylglycine iyindawo esetshenziselwa ukulungiswa kokwenziwa kwe-β-lactam antibiotic. I-4-hydroxy-d - (-) - 2-phenylglycine (cefadroxil EP ukungcola a (Amoxicillin EP ukungcola a)) kuyindawo esetshenziselwa ukulungiswa kwe-β-lactam.
Isingeniso Esinemininingwane
I-4-hydroxy-d-phenylglycine, eyaziwa nangokuthi ama-4-hddroxy-d-phenylllycine noma i-4-HDPG, iyindawo yamakhemikhali ngefomula ye-molecular c8h9no3. Kuyinto esuselwa e-Amino Acid futhi ingeyasesigabeni se-PhenylllyCines.4-Hydroxy-d-phenylllycine ngokuyinhloko isetshenziswa njengebhulokhi yokwakha ekuhlanganiseni kwamakhompiyutha ezemithi. Kusebenza njengento eluhlaza ekwenziweni kwama-antibiotic athile, njenge-cefadroxil ne-cephradine. Lawa magciwane angowesigaba se-cephalorporin futhi asetshenziselwa ukwelapha ukutheleleka kwamagciwane.Izengezo endimeni yayo njengokwandulela kokuhlanganiswa kwemithi, 4-hydroxy-d-phenylllcine nayo ishintshiwe ngezakhiwo zayo zokwelapha ezingaba khona. Ucwaningo luphakamisa ukuthi lungaba nemiphumela ye-antioxidant ne-anti-ukuvuvukala, ebingayenza ilusizo ekuthuthukisweni kwezidakamizwa ezintsha zezimo ezahlukahlukene zezokwelapha.overall, i-4-hydroxy-d-phenylysic isetshenziswa zokwelapha ezingaba khona. Indima yayo njengebhulokhi yokwakha ekwakhiweni kwama-antibiotics iqokomisa ukubaluleka kwayo embonini yezemithi.
