2,4-Diamino-6-hydroxypyrimidine

Incazelo emfushane:

Igama Lomkhiqizo:2,4-Diamino-6-hydroxypyrimidine

Omqondofana:I-TIMTEC-BB SBB004252;2,4-DIAMINOPYRIMIDIN-6-OL;2,4-DIAMINO-6-HYDROXYPYRIMIDINE;2,4-DIAMINO-6-PYRIMIDINOL;2,4-DIAMINO-6(1H)-PYRIMIDINONE;2,2; 6-DIAMINO-4-PYRIMIDINOL;2,6-DIAMINO-4-PYRIMIDINONE;2,6-DIAMINOPYRIMIDIN-4-OL

I-CAS:56-06-4

MF:I-C4H6N4O

MW:126.12

I-EINECS:200-254-4

Izigaba zomkhiqizo:I-Pyrimidines;Amabhulokhi Okwakha;PYRIMIDINE;C4 kuya ku-C5;I-Chemical Synthesis;I-Heterocyclic Building Blocks;Ama-API & I-Intermediate;Ama-Pyridine, ama-Pyrimidine, ama-Purines nama-Pteredines;Ama-Chemical Amines;I-13C & 2H Ushukela;Ama-Amine;Izisekelo nama-Heterootihydrates; & Okuphuma;bc0001

Ifayela le-Mol:56-06-4.mol

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-Hydroxypyrimidine Chemical Properties

Iphoyinti lokuncibilika	285-286 °C (dec.) (lit.)
Iphuzu elibilayo	234.22°C (isilinganiso esinzima)
ukuminyana	1.3659 (isilinganiso esinzima)
inkomba ye-refractive	1.7990 (isilinganiso)
izinga lokushisa lokugcina.	Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi
ukuncibilika	I-DMSO (Kancane), i-Methanol (Kancane)
pka	10.61±0.50(Okubikezelwe)
ifomu	I-Crystalline Powder Enhle
umbala	Okumhlophe kuya kukhilimu
Kuyazwela	Ukukhanya Okuzwelayo
I-Merck	14,2981
I-BRN	125006
I-InChIKey	SWELIMKTDYHAOY-UHFFFAOYSA-N
Ireferensi ye-CAS Database	56-06-4(CAS DataBase Reference)
I-NIST Chemistry Reference	4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
I-EPA Substance Registry System	2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

Incazelo Yomkhiqizo we-Hydroxypyrimidine

I-2,4-Diamino-6-hydroxypyrimidine iyinhlanganisela yamakhemikhali ene-molecular formula C4H6N4O.Kuyinhlanganisela ephilayo yomndeni we-pyrimidine.I-compound inesakhiwo sendandatho ye-pyrimidine, amaqembu amabili e-amino (NH2) axhunywe ku-2-position kanye ne-4-position, futhi iqembu le-hydroxyl (OH) lixhunywe endaweni ye-6.Isakhiwo samakhemikhali singavezwa njenge: Ammonia ||H--C--C--C--N--C--C--NH2 ||oh 2,4-Diamino-6-hydroxypyrimidine inezinhlelo zokusebenza ezahlukahlukene embonini yezemithi.Iyingxenye ebalulekile yokuhlanganiswa kwezidakamizwa eziningi, kuhlanganise nezidakamizwa ze-antiviral kanye ne-antitumor.Ibuye isetshenziselwe ukukhiqiza ama-nucleotide analog amaningana asetshenziswa ocwaningweni lwezemithi.

Ngaphandle kwezicelo zemithi, i-2,4-diamino-6-hydroxypyrimidine iphinde isetshenziswe njengesithako kumakhemikhali e-agrochemicals.Kuyisithako esibalulekile ekuhlanganisweni kwezilawuli zokukhula kwezitshalo nama-fungicides.Kubaluleke kakhulu ukulandela umthetho olandelwayo wokuphepha uma usebenzisa i-2,4-diamino-6-hydroxypyrimidine.Njengoba ihlukaniswa njenge-chemical irritant, kufanele iphathwe ngokucophelela futhi izinto zokuzivikela ezanele kufanele zigqokwe ukuze kugwenywe ukuthintana okuqondile.

Kafushane, i-2,4-diamino-6-hydroxypyrimidine iyinhlanganisela ephilayo enezicelo emikhakheni yezemithi nezolimo.Ukwakheka kwayo kwamakhemikhali kuyenza ibe wusizo njengendawo ephakathi ekuhlanganiseni imithi kanye nezilawuli zokukhula kwezitshalo.

Ulwazi Lokuphepha

Amakhodi Wengozi	Xi
Izitatimende Zobungozi	36/37/38
Izitatimende Zokuphepha	22-24/25-36-26
I-WGK Germany	3
Inothi Lengozi	Iyacasula
I-TSCA	Yebo
Ikhodi ye-HS	29335995

Ukusetshenziswa kweHydroxypyrimidine kanye Nokuhlanganiswa

Incazelo	I-2,4-Diamino-6-hydroxypyrimidine (DAHP) iyisivimbeli esikhethekile, esikhethekile se-GTP cyclohydrolase I, isinyathelo sokukhawulela isilinganiso se-de novo pterin synthesis.Kumaseli e-HUVEC, i-IC₅₀ukuze kuvinjwe i-BH₄I-biosynthesis cishe i-0.3 mM.I-DAHP ingasetshenziswa ukuvimba ngempumelelo AKUKHO ukukhiqizwa ezinhlotsheni zamaseli eziningana.
Chemical Properties	Okuqinile Okumhlophe
Isebenzisa	I-2,4-Diamino-6-hydroxypyrimidine (DAHP) iyisivimbeli esikhethekile, esikhethekile se-GTP cyclohydrolase I, isinyathelo sokukhawulela isilinganiso se-de novo pterin synthesis.Kumaseli e-HUVEC, i-IC50 yokuvinjwa kwe-BH4 biosynthesis icishe ibe ngu-0.3 mM.I-DAHP ingasetshenziswa ukuvimba ngempumelelo AKUKHO ukukhiqizwa ezinhlotsheni ezimbalwa zamaseli.[Cayman Chemical]
Isebenzisa	Ima ekuqaleni kwe-enzyme-catalyzed cascade eqala ngale carbohydrate eyi-7-carbon futhi igcine ngama-amino acid anephunga elimnandi i-phenylalanine, i-tyrosine, ne-tryptophan.
Isebenzisa	I-2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) iyinhlanganisela ewusizo ku-organic synthesis.
Izindlela Zokuhlanza	Iphinda icwebe isuka ku-H2O.[Beilstein 25 III/IV 3642.]