Imikhiqizo
2,4-Diamino-6-hydroxypyrimidine 2,6-Diamino-4-Hydroxyprimidine
Synonyms:4(1H) -Pyrimidinone,2,6-diamino- (8CI,9CI);2,4-Diamino-6-hydroxypyrimidine;2,4-Diamino-6-pyrimidinone;2,6-Diamino-3,4 -dihydropyrimidin-4-one;2,6-Diamino-4 (1H) -pyrimidinone;2,6-Diamino-4 (3H) -pyrimidinone;2,6-Diamino-4-hydroxypyrimidine;2,6-Diamino-4 -pyrimidinol;2,6-Diaminopyrimidin-4-one;2,6-Diaminopyrimidine-4 (3H) -one;6-Aminoisocytosine;6-Hydroxy-2,4-pyrimidinediamine;NSC 44914;NSC 680818;NSC9302;
I-Chemical Property ye-2,4-Diamino-6-hydroxypyrimidine
● Ukubukeka/Umbala:okuqinile okumhlophe
● Umfutho Wokuhwamuka:0.00232mmHg ku-25°C
● Indawo Encibilika:285-286 °C (dec.)(lit.)
● I-Refractive Index:1.7990 (isilinganiso)
● Indawo yokubilisa:288.5 °C ku-760 mmHg
● I-PKA:10.61±0.50(Kubikezelwe)
● Iphuzu Elikhanyayo:128.3 °C
● I-PSA:98.05000
● Ukuminyana:1.84 g/cm3
● I-LogP:0.50900
● Ukushisa Kwesitoreji.: Nciphisa ku-+4°C
● Kuyazwela.:Kuzwela ukukhanya
● Ukunyibilika.:DMSO (Kancane), i-Methanol (Kancane)
Ubumsulwa/Ikhwalithi
99% *idatha evela kubahlinzeki abangavuthiwe
2,4-Diamino-6-hydroxypyrimidine *idatha evela kubanikezeli be-reagent
Ulwazi Oluphephile
● Ama-Pictogram:
Xi
● Amakhodi Wengozi:Xi
● Izitatimende:36/37/38
● Izitatimende Zokuphepha:22-24/25-36-26
Iwusizo
● Incazelo: I-2,4-Diamino-6-hydroxypyrimidine (DAHP) iyisivimbeli esikhethekile, esikhethekile se-GTP cyclohydrolase I, isinyathelo sokukhawulela isilinganiso se-de novo pterin synthesis.Kumaseli e-HUVEC, i-IC50 yokuvinjwa kwe-BH4 biosynthesis icishe ibe ngu-0.3 mM.I-DAHP ingasetshenziswa ukuvimba ngempumelelo AKUKHO ukukhiqizwa ezinhlotsheni zamaseli eziningana.
● Ukusetshenziswa: I-2,4-Diamino-6-hydroxypyrimidine (DAHP) iyisivimbeli esikhethekile, esikhethekile se-GTP cyclohydrolase I, isinyathelo sokunciphisa isilinganiso se-de novo pterin synthesis.Kumaseli e-HUVEC, i-IC50 yokuvinjwa kwe-BH4 biosynthesis icishe ibe ngu-0.3 mM.I-DAHP ingasetshenziswa ukuvimba ngempumelelo u-NO ukukhiqizwa ezinhlotsheni zamaseli eziningana.[Cayman Chemical] Ima ekuqaleni kwe-enzyme-catalyzed cascade eqala ngale carbohydrate eyi-7 carbon futhi igcine ngama-amino acid anephunga elimnandi i-phenylalanine, i-tyrosine, ne-tryptophan. I-2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) iyinhlanganisela ewusizo ku-organic synthesis.
I-2,4-Diamino-6-hydroxypyrimidine iyinhlanganisela yamakhemikhali ene-molecular formula C4H6N4O.Ivame ukusetshenziswa njengendawo ephakathi ekuhlanganisweni kwezinhlanganisela ezihlukahlukene, kuhlanganise nezidakamizwa zemithi kanye namadayi.I-compound inesakhiwo sendandatho ye-pyrimidine ehlanganisa amaqembu amabili amino (NH2) kanye neqembu elilodwa le-hydroxyl (OH) elixhunywe kuma-athomu e-carbon ahlukene.Lesi sakhiwo senza kube yisakhiwo esinemisebenzi eminingi yokuhlanganiswa kwama-molecule ayinkimbinkimbi.2,4-Diamino-6-hydroxypyrimidine ingatholakala ngezindlela ezihlukahlukene zokwenziwa, kuhlanganise nokusabela kwe-cyanamide nge-urea.Inezinhlelo zokusebenza eziningana embonini yezemithi, ikakhulukazi ekuhlanganisweni kwezidakamizwa ezilwa nomdlavuza kanye nama-antibiotics.Sekukonke, i-2,4-Diamino-6-hydroxypyrimidine iyinhlanganisela ebalulekile ethola usizo ezinhlobonhlobo zamakhemikhali nemithi.
