Imikhiqizo
2,4-diamano-6-hydroxyperine; Case No.: 56-06-4
Ama-Synonyms: 4 (1h) -I-Pyrimidinone, 2,6-Diameno- (8ci, 9ci); I-2,4-diamano-6-hydroxyperine; 2,4-diamano-6 I-2,6-Diamano-4-Hydroxyperimine; 2,6-Pydroxy-4-Pyrimidinol; 2,6-Diadinopymin-4 (3-diadinopymine-4 (3h-diadinopymine-4 (3h-diadinopymine-4 (3h-diameisocytosine; 6-hydroxy-2,4-pyrimidiamine; NSC 44914; NSC 680818; NSC9302;
Impahla yamakhemikhali ye-2,4-diamano-6-hydroxyyyimidine
● Ukubukeka / umbala: okumhlophe okuqinile
● Ingcindezi ye-Vapor: 0.00232mmhg ngo-25 ° C
● Iphuzu elincibilikayo: 285-286 ° C (Dec.) (Lit.)
● Inkomba yokuqapha: 1.7990 (Linganisa)
● Iphuzu elibilayo: 288.5 ° C ku-760 mmhg
● I-PKA: 10.61 ± 0.50 (Ebikezelwe)
● Iphuzu le-Flash: 128.3 ° C
● PSA: 98.05000
● Hlensity: 1.84 g / cm3
● logp: 0.50900
● Isitoreji Temp.:Desiccate at + 4 ° C
● I-SENTITITE.: Ukuzikhandla kuzwela
● I-Solubity.:DMSO (kancane), Methanol (kancane)
Imininingwane Ephelile
● pictograph (s):
Xi
● Amakhodi Ayingozi: XI
● Izitatimende: 36/37/38
● Izitatimende zokuphepha: 22-24/15-36-26
-Sizayo
● Ukuchazwa: 2,4-Diamano-6-HydroxyyyImine (Dahp) iyinhlangano ekhethiwe, ekhethekile ye-GTP cyclohyrolase i, isilinganiso sokukhawulelwa kwesinyathelo se-de Novo Pterin Synthesis. Ku-Huvec cell, i-IC50 yokuvinjwa kwe-BH4 Biosynthesis cishe ngo-0,3 mm. I-DAHP ingasetshenziswa ukuvimba ngempumelelo ukukhiqizwa kwezinhlobo eziningi zeseli.
● Sebenzisa: 2,4-diameno-6-hydroxyyylidine (Dahp) iyinhlangano ekhethiwe, ekhethekile ye-gtp cyclohyrolase i, isilinganiso sokukhawulelwa kwesinyathelo se-de Novo Pterin Synthesis. Ku-Huvec cell, i-IC50 yokuvinjwa kwe-BH4 Biosynthesis cishe ngo-0,3 mm. I-DAHP ingasetshenziswa ukuvimba ngempumelelo ukukhiqizwa kwezinhlobo eziningana zeseli. [Cayman Chemical] Ima ekuqaleni kwe-enzyme-carbohyddrate eqala ngaleli I-Compound ewusizo ekuhlanganiseni kwe-organic.
I-2,4-Diamano-6-HydroxyyyIdine iyindawo yamakhemikhali ngefomula ye-molecular c4h6n4o. Isetshenziswa kakhulu njengomphakathi ekuhlanganiseni kwamakhompiyutha ahlukahlukene, kufaka phakathi izidakamizwa kanye ne-dyses.I-Compound inesakhiwo se-pyrimidine ring ekhethwe ama-athomu amabili we-amino (oh) anamathele kuma-athomu e-carbon ahlukene. Lesi sakhiwo sikwenza kube yibhulokhi yokwakha eguquguqukayo yokuhlanganiswa kwama-molecule ama-molecule amahle kakhulu.2,4-diamano-6-hydroxyyidine angatholakala ngezindlela ezahlukahlukene zokwenziwa, kufaka phakathi ukusabela kwe-cyanamide nge-urea. Inezicelo eziningana embonini yezemithi, ikakhulukazi ekuhlanganiseni kwezidakamizwa zezi-anticancer kanye nama-antibiotic.ovel, ama-2,4-diamDoxyyIdine, ama-2,4-hydroxyyidine kuyinto ebalulekile ethola ukusetshenziswa kwezicelo ezahlukahlukene zamakhemikhali kanye nemithi.
Isingeniso Esinemininingwane
I-2,4-Diamano-6-HydroxyyyIdine iyindawo yamakhemikhali ngefomula ye-molecular c4h6n4o. Kuyinto ehlanganisiwe yomndeni we-pyrimidine. I-Compound inesakhiwo sendandatho se-pyymidine, amaqembu amabili e-amino (NH2) axhunyiwe esimweni esingu-2 nesikhundla esingu-4, kanye neqembu le-hydroxyl (oh) lixhunyiwe esimweni esingu-6. Isakhiwo samakhemikhali singavezwa ngokuthi: I-Amonia | | H - C - C - C - N - C - C - NH2 | | HH 2,4-Diamano-6-HydroxyyyIdine unezicelo ezahlukahlukene embonini yezemithi. Kungumkhawulo obalulekile ekuhlanganiseni kwezidakamizwa eziningi, kubandakanya nezidakamizwa ezi-antiviral ne-antitumor. Kusetshenziselwa futhi ukukhiqiza ama-analog ambalwa we-nucleotide asetshenziswe ocwaningweni lwezemithi.
Ngaphezu kwezicelo zemithi, kusetshenziswe ama-2,4-diamano-6-hydroxypeimidine futhi kusetshenziswa njengesithako ku-agrochemicals. Kuyisithako esiyisihluthulelo sokuhlanganiswa kwezindawo zokukhula kwezitshalo kanye nama-fungicides. Kubaluleke kakhulu ukulandela uhlelo lokuphepha olufanele lapho usebenzisa ama-2,4-diam-diameno-6-hydroxyyyimidine. Njengoba ihlukaniswa njenge-Chemical Ecasukayo, kufanele iphathwe ngokunakekela kanye nemishini yokuzivikela yomuntu siqu kufanele igqoke ukugwema ukuxhumana ngqo.
Ngamafuphi, ama-2,4-diamano-6-hydroxyperine yingxenye ye-organic anezinhlelo zokusebenza ezinkambeni zezemithi nezolimo. Isakhiwo saso samakhemikhali senza kube wusizo njengomphakathi ngokuhlanganiswa kwemithi kanye nabalawuli bokukhula kwezitshalo.
